[Download] "Effect of Two Common Polymorphisms in the ATP Binding Cassette Transporter A1 Gene on Hdl-Cholesterol Concentration (Technical Briefs)" by Clinical Chemistry * eBook PDF Kindle ePub Free

July 06, 2021

Effect of Two Common Polymorphisms in the ATP Binding Cassette Transporter A1 Gene on Hdl-Cholesterol Concentration (Technical Briefs)

eBook details

Title: Effect of Two Common Polymorphisms in the ATP Binding Cassette Transporter A1 Gene on Hdl-Cholesterol Concentration (Technical Briefs)
Author : Clinical Chemistry
Release Date : January 01, 2005
Genre: Chemistry,Books,Science & Nature,
Pages : * pages
Size : 190 KB

Description

HDL-cholesterol (HDL-C) has long been recognized as having an atheroprotective role (1). Epidemiologic studies have shown that decreased HDL-C concentrations are the most common lipid abnormality in patients with premature coronary artery disease (CAD). Thus, there has been increased recognition of the inverse relationship between HDL-C concentrations and risk for CAD (2,3). This heightened awareness is underscored by changes in the recommendations of the Adult Treatment Panel (ATP) of the National Cholesterol Education Program. For example, ATP 11, published in 1993, first introduced the concept of a low HDL-C [0.91 mmol/L (35 mg/dL)] as a risk factor for CAD (4). More recently, ATP III further revised the cutoff for HDL-C as a risk factor to 1.04 mmol/L (40 mg/dL) (5). HDL-C is the primary lipoprotein particle responsible for reverse cholesterol transport (RCT) (6). RCT involves the transport of cholesterol from nonhepatic cells to the liver and its subsequent elimination from the body as bile acid and free cholesterol. A major advance in the understanding of RCT was heralded by the discovery of the gene encoding for ATP binding cassette transporter A1 (ABCA1). ABCA1, a member of the ABC transporter family, facilitates the active transport of cholesterol and phospholipids from the intracellular compartments of peripheral cells to the lipid-poor nascent HDL particle (7), thus representing the first step of the RCT pathway.