[Download] "Effect of Vitamin E Supplementation with Standard Treatment on Oxidant-Antioxidant Status in Chronic Obstructive Pulmonary Disease (Report)" by Indian Journal of Medical Research ~ Book PDF Kindle ePub Free

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eBook details

• Title: Effect of Vitamin E Supplementation with Standard Treatment on Oxidant-Antioxidant Status in Chronic Obstructive Pulmonary Disease (Report)
• Author : Indian Journal of Medical Research
• Release Date : January 01, 2008
• Genre: Life Sciences,Books,Science & Nature,
• Pages : * pages
• Size : 216 KB

Description

Background & objectives: Chronic oxidant burden and depletion of endogenous antioxidants have been proposed to play a key role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Exogenous antioxidants have potential therapeutic implications and their role has not been explored in COPD. The objective of this study was to investigate the effect of supplementation of standard treatment (inhaled long-acting [[beta].sub.2] agonists, anticholinergics and corticosteroids) with vitamin E on oxidant-antioxidant balance in patients with COPD. Methods: The study was carried out in the outpatient setting. Patients were divided into two groups: group A-placebo group (n=14), receiving only standard therapy, and group B-vitamin E-supplemented group (n=10), receiving 400 IU of vitamin E capsules twice daily in addition to standard therapy. Spirometry and clinical assessment were carried out at the start and completion of 8 wk treatment along with measurements of several biochemical parameters of oxidant-antioxidant status in plasma, leukocytes and red cells separated from venous blood.

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