[DOWNLOAD] "Effectiveness and Tolerability of a Standardized Extract from Hibiscus Sabdariffa in Patients with Mild to Moderate Hypertension: A Controlled and Randomized Clinical Trial ([??]) (Research Findings)" by Phytomedicine: International Journal of Phytotherapy & Phytopharmacology # Book PDF Kindle ePub Free

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• Title: Effectiveness and Tolerability of a Standardized Extract from Hibiscus Sabdariffa in Patients with Mild to Moderate Hypertension: A Controlled and Randomized Clinical Trial ([??]) (Research Findings)
• Author : Phytomedicine: International Journal of Phytotherapy & Phytopharmacology
• Release Date : January 01, 2004
• Genre: Life Sciences,Books,Science & Nature,
• Pages : * pages
• Size : 257 KB

Description

Abstract In order to compare the antihypertensive effectiveness and tolerability of a standardized extract from Hibiscus sabdariffa with captopril, a controlled and randomized clinical trial was done. Patients from 30 to 80 years old with diagnosed hypertension and without antihypertensive treatment for at least 1 month before were included. The experimental procedure consisted of the administration of an infusion prepared with 10g of dry calyx from H. sabdariffa on 0.51 water (9.6 mg anthocyanins content), daily before breakfast, or captopril 25 mg twice a day, for 4 weeks. The outcome variables were tolerability, therapeutic effectiveness (diastolic reduction [greater than or equal to] 10 mm Hg) and, in the experimental group, urinary electrolytes modification. Ninety subjects were included, 15 withdrew from the study due to non-medical reasons; so, the analysis included 39 and 36 patients from the experimental and control group, respectively. The results showed that H. sabdariffa was able to decrease the systolic blood pressure (BP) from 139.05 to 123.73 mm Hg (ANOVA p 0.03) and the diastolic BP from 90.81 to 79.52 mm Hg (ANOVA p 0.06). At the end of the study, there were no significant differences between the BP detected in both treatment groups (ANOVA p 0.25). The rates of therapeutic effectiveness were 0.7895 and 0.8438 with H. sabdariffa and captopril, respectively ([X.sup.2], p 0.560), whilst the tolerability was 100% for both treatments. A natriuretic effect was observed with the experimental treatment. The obtained data confirm that the H. sabdariffa extract, standardized on 9.6 mg of total anthocyanins, and captopril 50 mg/day, did not show significant differences relative to hypotensive effect, antihypertensive effectiveness, and tolerability.

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